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      Physiology of Astroglia

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      Physiological Reviews
      American Physiological Society

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          Abstract

          Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in morphological appearance; they express a multitude of receptors, channels, and membrane transporters. This complement underlies their remarkable adaptive plasticity that defines the functional maintenance of the CNS in development and aging. Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.

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          Author and article information

          Journal
          Physiol Rev
          Physiol. Rev
          physrev
          Physiol Rev
          PHYSREV
          Physiological Reviews
          American Physiological Society (Bethesda, MD )
          0031-9333
          1522-1210
          1 January 2018
          13 December 2017
          1 January 2019
          : 98
          : 1
          : 239-389
          Affiliations
          The University of Manchester , Manchester, United Kingdom; Achúcarro Basque Center for Neuroscience, IKERBASQUE, Basque Foundation for Science , Bilbao, Spain; Department of Neuroscience, University of the Basque Country UPV/EHU and CIBERNED, Leioa, Spain; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen, Denmark; and Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, New York
          Article
          PMC6050349 PMC6050349 6050349 PRV-00042-2016 PRV-00042-2016
          10.1152/physrev.00042.2016
          6050349
          29351512
          eca14015-f11a-4517-8df6-dbc3ba57f42b
          Copyright © 2018 the American Physiological Society
          History
          : 20 December 2016
          : 22 March 2017
          : 27 April 2017
          Funding
          Funded by: HHS | National Institutes of Health (NIH) 10.13039/100000002
          Categories
          Review

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