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      An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots.

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          The remodeling of root architecture is a major developmental response of plants to phosphate (Pi) deficiency and is thought to enhance a plant's ability to forage for the available Pi in topsoil. The underlying mechanism controlling this response, however, is poorly understood. In this study, we identified an Arabidopsis mutant, hps10 (hypersensitive to Pi starvation 10), which is morphologically normal under Pi sufficient condition but shows increased inhibition of primary root growth and enhanced production of lateral roots under Pi deficiency. hps10 is a previously identified allele (als3-3) of the ALUMINUM SENSITIVE3 (ALS3) gene, which is involved in plant tolerance to aluminum toxicity. Our results show that ALS3 and its interacting protein AtSTAR1 form an ABC transporter complex in the tonoplast. This protein complex mediates a highly electrogenic transport in Xenopus oocytes. Under Pi deficiency, als3 accumulates higher levels of Fe(3+) in its roots than the wild type does. In Arabidopsis, LPR1 (LOW PHOSPHATE ROOT1) and LPR2 encode ferroxidases, which when mutated, reduce Fe(3+) accumulation in roots and cause root growth to be insensitive to Pi deficiency. Here, we provide compelling evidence showing that ALS3 cooperates with LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by modulating Fe homeostasis in roots.

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          Author and article information

          Mol Plant
          Molecular plant
          Elsevier BV
          Feb 13 2017
          : 10
          : 2
          [1 ] Ministry of Education Key Laboratory of Bioinformatics, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
          [2 ] USDA-ARS, Robert Holley Center for Agriculture and Health, Cornell University, Ithaca, NY 14580, USA.
          [3 ] Department of Horticulture, Purdue University, West Lafayette, IN 47907-2010, USA.
          [4 ] State Key Laboratory of Plant Physiology and Biochemistry, College of Life Science, Zhejiang University, Hangzhou 310058, China.
          [5 ] Department of Plant Science and Landscape Architecture, University of Maryland, College Park, MD 20742, USA.
          [6 ] Global Institute for Food Security, University of Saskatchewan, Saskatoon S7N 4J8, Canada.
          [7 ] Ministry of Education Key Laboratory of Bioinformatics, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: liu-d@mail.tsinghua.edu.cn.

          ABC transporter,ALUMINUM SENSITIVE3,AtSTAR1,iron homeostasis,phosphate deficiency,root architecture


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