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      Effect of the Growth Hormone-Secreting Tumor StW5 on Pituitary and Adrenal Gland Function in Rats

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          Abstract

          A growth hormone-secreting tumor (StW5) was implanted into male rats and resulted in a tripling of adrenal weight concomitant with a 30% decrement in pituitary weight. Plasma concentrations of corticosterone in tumor-bearing (TB) rats were significantly elevated at rest or after ACTH injections or the stress of ether anesthesia. The rise in plasma concentrations of corticosterone was due mainly to the large increment in adrenal size although a significant increase in adrenal responsiveness to ACTH was demonstrated in vitro. In addition, plasma corticosterone concentrations were higher in TB rats despite both a doubling of the blood volume and a 50% increase in liver capacity to metabolize corticosterone. Pituitary ACTH content was significantly lower in TB rats, but these pituitary glands could still release near-normal quantities of ACTH as shown both by in vitro incubations and adrenal corticosterone output following ether stress.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1981
          1981
          25 November 2008
          : 14
          : 1
          : 36-46
          Affiliations
          Department of Biological Sciences, Wellesley College, Wellesley, Mass., USA
          Article
          179355 Horm Res 1981;14:36–46
          10.1159/000179355
          6266940
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 11
          Categories
          Original Paper

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