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      Protein-lipid interplay in fusion and fission of biological membranes.

      1 ,
      Annual review of biochemistry
      Annual Reviews

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          Abstract

          Disparate biological processes involve fusion of two membranes into one and fission of one membrane into two. To formulate the possible job description for the proteins that mediate remodeling of biological membranes, we analyze the energy price of disruption and bending of membrane lipid bilayers at the different stages of bilayer fusion. The phenomenology and the pathways of the well-characterized reactions of biological remodeling, such as fusion mediated by influenza hemagglutinin, are compared with those studied for protein-free bilayers. We briefly consider some proteins involved in fusion and fission, and the dependence of remodeling on the lipid composition of the membranes. The specific hypothetical mechanisms by which the proteins can lower the energy price of the bilayer rearrangement are discussed in light of the experimental data and the requirements imposed by the elastic properties of the bilayer.

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          Author and article information

          Journal
          Annu Rev Biochem
          Annual review of biochemistry
          Annual Reviews
          0066-4154
          0066-4154
          2003
          : 72
          Affiliations
          [1 ] Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, NICHD, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1855, USA. lchern@helix.nih.gov
          Article
          10.1146/annurev.biochem.72.121801.161504
          14527322
          ecb9fc0f-9e78-45de-a91a-2764d2d4b16e
          History

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