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      Bilateral cystoid macular edema following docetaxel chemotherapy in a patient with retinitis pigmentosa: a case report

      case-report

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          Abstract

          Background

          Docetaxel is a chemotherapeutic agent of the taxane class of drugs for the treatment of breast cancer. We present a female patient who noted decreased vision after docetaxel treatment.

          Case presentation

          A 45-year-old female patient received docetaxel treatment after resection of a breast carcinoma. Funduscopy and optical coherence tomography (OCT) showed cystoid macular edema on both eyes. Dilated funduscopy also showed bone spicule-like pigmented deposits, typical for retinitis pigmentosa. Besides the fundus appearance restricted peripheral vision and scotopic electroretinogram confirmed the diagnosis of retinitis pigmentosa. Chemotherapy was discontinued following a consulation with the oncologist of the patient. After five weeks, visual acuity improved significantly along with decrease of retinal thickness measured by OCT.

          Conclusion

          Docetaxel may cause ocular adverse effects such as cystoid macular edema. Ophthalmological examination is warranted for patients with visual complaints during docetaxel chemotherapy.

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          Most cited references16

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          Wide-field fundus autofluorescence imaging of retinitis pigmentosa.

          To evaluate the clinical usefulness of wide-field fundus autofluorescence (FAF) imaging in patients with retinitis pigmentosa (RP).
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            Toxic neuropathy in patients with pre-existing neuropathy.

            The authors report significant worsening of a pre-existing neuropathy in six patients who received "non-toxic" dosages of known neurotoxic agents. Before treatment, baseline total neuropathy score (TNS) averaged 9.5 (range 0 to 19). After chemotherapy (Taxol [125 to 175 mg/m(2) x 4]; vincristine [2 to 5 mg]; cisplatin [40 mg/m(2) x 8]; and thalidomide [60 g]), the TNS averaged 22 (range 13 to 29). The authors conclude that functionally disabling toxic neuropathy can occur in patients with pre-existing neuropathy at standard doses.
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              Paclitaxel maculopathy.

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                Author and article information

                Contributors
                enzsoly.anna@med.semmelweis-univ.hu
                kkammerer@florhosp.hu
                nemeth.janos@med.semmelweis-univ.hu
                schneider.miklos@med.semmelweis-univ.hu
                Journal
                BMC Ophthalmol
                BMC Ophthalmol
                BMC Ophthalmology
                BioMed Central (London )
                1471-2415
                29 March 2015
                29 March 2015
                2015
                : 15
                : 32
                Affiliations
                [ ]Department of Ophthalmology, Semmelweis University, Faculty of Medicine, H-1085 Maria u. 39, Budapest, Hungary
                [ ]Department of Oncology, Flor Ferenc Hospital of Pest County, Kistarcsa, Hungary
                Article
                20
                10.1186/s12886-015-0020-4
                4392864
                25885440
                ecc8da9f-a1d3-4899-bb8d-3a8e1c8e3a57
                © Enzsoly et al.; licensee BioMed Central. 2015

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 29 October 2014
                : 19 March 2015
                Categories
                Case Report
                Custom metadata
                © The Author(s) 2015

                Ophthalmology & Optometry
                docetaxel,cystoid macular edema,optical coherence tomography,retinitis pigmentosa

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