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      Macrophage regulation of tumor responses to anticancer therapies.

      1 ,
      Cancer cell
      Elsevier BV

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          Abstract

          Tumor-associated macrophages (TAMs) promote key processes in tumor progression, like angiogenesis, immunosuppression, invasion, and metastasis. Increasing studies have also shown that TAMs can either enhance or antagonize the antitumor efficacy of cytotoxic chemotherapy, cancer-cell targeting antibodies, and immunotherapeutic agents--depending on the type of treatment and tumor model. TAMs also drive reparative mechanisms in tumors after radiotherapy or treatment with vascular-targeting agents. Here, we discuss the biological significance and clinical implications of these findings, with an emphasis on novel approaches that effectively target TAMs to increase the efficacy of such therapies.

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          Author and article information

          Journal
          Cancer Cell
          Cancer cell
          Elsevier BV
          1878-3686
          1535-6108
          Mar 18 2013
          : 23
          : 3
          Affiliations
          [1 ] The Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne, Switzerland. michele.depalma@epfl.ch
          Article
          S1535-6108(13)00069-X
          10.1016/j.ccr.2013.02.013
          23518347
          ecca5805-4a1a-4897-95ad-1833fba6c962
          Copyright © 2013 Elsevier Inc. All rights reserved.
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