Psychological therapies for parents of children and adolescents with chronic illness
aim to improve parenting behavior and mental health, child functioning (behavior/disability,
mental health, and medical symptoms), and family functioning. This is an updated version
of the original Cochrane Review (2012) which was first updated in 2015. To evaluate
the efficacy and adverse events of psychological therapies for parents of children
and adolescents with a chronic illness. We searched CENTRAL, MEDLINE, Embase, PsycINFO,
and trials registries for studies published up to July 2018. Included studies were
randomized controlled trials (RCTs) of psychological interventions for parents of
children and adolescents with a chronic illness. In this update we included studies
with more than 20 participants per arm. In this update, we included interventions
that combined psychological and pharmacological treatments. We included comparison
groups that received either non‐psychological treatment (e.g. psychoeducation), treatment
as usual (e.g. standard medical care without added psychological therapy), or wait‐list.
We extracted study characteristics and outcomes post‐treatment and at first available
follow‐up. Primary outcomes were parenting behavior and parent mental health. Secondary
outcomes were child behavior/disability, child mental health, child medical symptoms,
and family functioning. We pooled data using the standardized mean difference (SMD)
and a random‐effects model, and evaluated outcomes by medical condition and by therapy
type. We assessed risk of bias per Cochrane guidance and quality of evidence using
GRADE. We added 21 new studies. We removed 23 studies from the previous update that
no longer met our inclusion criteria. There are now 44 RCTs, including 4697 participants
post‐treatment. Studies included children with asthma (4), cancer (7), chronic pain
(13), diabetes (15), inflammatory bowel disease (2), skin diseases (1), and traumatic
brain injury (3). Therapy types included cognitive‐behavioural therapy (CBT; 21),
family therapy (4), motivational interviewing (3), multisystemic therapy (4), and
problem‐solving therapy (PST; 12). We rated risk of bias as low or unclear for most
domains, except selective reporting bias, which we rated high for 19 studies due to
incomplete outcome reporting. Evidence quality ranged from very low to moderate. We
downgraded evidence due to high heterogeneity, imprecision, and publication bias.
Evaluation of parent outcomes by medical condition Psychological therapies may improve
parenting behavior (e.g. maladaptive or solicitous behaviors; lower scores are better)
in children with cancer post‐treatment and follow‐up (SMD −0.28, 95% confidence interval
(CI) −0.43 to −0.13; participants = 664; studies = 3; SMD −0.21, 95% CI −0.37 to −0.05;
participants = 625; studies = 3; I 2 = 0%, respectively, low‐quality evidence), chronic
pain post‐treatment and follow‐up (SMD −0.29, 95% CI −0.47 to −0.10; participants
= 755; studies = 6; SMD −0.35, 95% CI −0.50 to −0.20; participants = 678; studies
= 5, respectively, moderate‐quality evidence), diabetes post‐treatment (SMD −1.39,
95% CI −2.41 to −0.38; participants = 338; studies = 5, very low‐quality evidence),
and traumatic brain injury post‐treatment (SMD −0.74, 95% CI −1.25 to −0.22; participants
= 254; studies = 3, very low‐quality evidence). For the remaining analyses data were
insufficient to evaluate the effect of treatment. Psychological therapies may improve
parent mental health (e.g. depression, anxiety, lower scores are better) in children
with cancer post‐treatment and follow‐up (SMD −0.21, 95% CI −0.35 to −0.08; participants
= 836, studies = 6, high‐quality evidence; SMD −0.23, 95% CI −0.39 to −0.08; participants
= 667; studies = 4, moderate‐quality evidence, respectively), and chronic pain post‐treatment
and follow‐up (SMD −0.24, 95% CI −0.42 to −0.06; participants = 490; studies = 3;
SMD −0.20, 95% CI −0.38 to −0.02; participants = 482; studies = 3, respectively, low‐quality
evidence). Parent mental health did not improve in studies of children with diabetes
post‐treatment (SMD −0.24, 95% CI −0.90 to 0.42; participants = 211; studies = 3,
very low‐quality evidence). For the remaining analyses, data were insufficient to
evaluate the effect of treatment on parent mental health. Evaluation of parent outcomes
by psychological therapy type CBT may improve parenting behavior post‐treatment (SMD
−0.45, 95% CI −0.68 to −0.21; participants = 1040; studies = 9, low‐quality evidence),
and follow‐up (SMD −0.26, 95% CI −0.42 to −0.11; participants = 743; studies = 6,
moderate‐quality evidence). We did not find evidence for a beneficial effect for CBT
on parent mental health at post‐treatment or follow‐up (SMD −0.19, 95% CI −0.41 to
0.03; participants = 811; studies = 8; SMD −0.07, 95% CI −0.34 to 0.20; participants
= 592; studies = 5; respectively, very low‐quality evidence). PST may improve parenting
behavior post‐treatment and follow‐up (SMD −0.39, 95% CI −0.64 to −0.13; participants
= 947; studies = 7, low‐quality evidence; SMD −0.54, 95% CI −0.94 to −0.14; participants
= 852; studies = 6, very low‐quality evidence, respectively), and parent mental health
post‐treatment and follow‐up (SMD −0.30, 95% CI −0.45 to −0.15; participants = 891;
studies = 6; SMD −0.21, 95% CI −0.35 to −0.07; participants = 800; studies = 5, respectively,
moderate‐quality evidence). For the remaining analyses, data were insufficient to
evaluate the effect of treatment on parent outcomes. Adverse events We could not evaluate
treatment safety because most studies (32) did not report on whether adverse events
occurred during the study period. In six studies, the authors reported that no adverse
events occurred. The remaining six studies reported adverse events and none were attributed
to psychological therapy. We rated the quality of evidence for adverse events as moderate.
Psychological therapy may improve parenting behavior among parents of children with
cancer, chronic pain, diabetes, and traumatic brain injury. We also found beneficial
effects of psychological therapy may also improve parent mental health among parents
of children with cancer and chronic pain. CBT and PST may improve parenting behavior.
PST may also improve parent mental health. However, the quality of evidence is generally
low and there are insufficient data to evaluate most outcomes. Our findings could
change as new studies are conducted. Psychological therapies for parents of children
and adolescents with a longstanding or life‐threatening physical illness Bottom line
We found that psychological therapies may improve parenting behavior for parents of
children with cancer, chronic pain, diabetes or traumatic brain injury, and may improve
mental health of parents of children with cancer or chronic pain. Cognitive‐behavioral
therapy (CBT) and problem‐solving therapy (PST) are promising types of therapy. We
were not able to answer questions about whether psychological therapies are helpful
for parents of children with other medical conditions, or whether other types of therapy
are helpful, because there were not enough data. Our findings may have been impacted
by differences in measures used across studies. New studies may change the results
of this review, and so our findings should be interpreted cautiously. Background We
have updated our previously published review of psychological therapies for parents
of children with a longstanding or life‐threatening physical illness to include studies
published through July 2018. Parenting a child with a longstanding illness is challenging.
Parents may have difficulty balancing caring for their child with other demands and
can experience increased stress, sadness, or family conflict. Their children may have
emotional or behavioral concerns. Parents can influence their child's adaptation to
living with their medical condition. Psychological therapies for parents provide training
in skills to modify emotions or behaviors that aim to improve parent, child, and family
well‐being. We wanted to understand whether psychological therapies are helpful for
parents of children and adolescents (up to age 19) with longstanding illness. We included
studies of interventions that were predominantly psychological and delivered to parents
compared with non‐psychological treatment, treatment as usual, or wait‐list. Outcomes
were parenting behavior (e.g. protective behaviors), parent mental health, child behavior/disability,
child mental health, child medical symptoms, family functioning, and side effects.
Key results We added 21 new studies in this update and we removed 23 studies that
no longer met our inclusion criteria, resulting in 44 randomized controlled trials
(randomized controlled trials, where participants are assigned randomly to either
one treatment or a different treatment or no treatment, provide the most reliable
evidence) with a total of 4697 participants (average child age = 11 years). The length
of the studies ranged from one day to 24 months. Studies included children with asthma
(4), cancer (7), chronic pain (recurrent or persistent pain for more than three months,
including two studies of children with inflammatory bowel disease (15)), diabetes
(15), skin diseases (1), and traumatic brain injury (3); one study included children
with eczema and children with asthma. Therapy types included CBT (21), family therapy
(4), motivational interviewing (3), multisystemic therapy (4), and PST (12). Funding
sources included federal and local governments, hospitals, universities, and foundations.
We found that parenting behavior improved in studies of children with cancer, chronic
pain, diabetes, and traumatic brain injury immediately after treatment, which continued
long‐term for parents of children with cancer and chronic pain. Parent mental health
improved in studies of children with cancer and chronic pain immediately after treatment,
which continued long‐term. Parent mental health did not improve in studies of children
with diabetes. We found that CBT and PST improved parenting behavior immediately after
treatment, which continued long‐term. PST also improved parent mental health immediately
after treatment and long‐term, but CBT did not. We could not evaluate whether the
other types of psychological therapy were beneficial for parents due to insufficient
data. We found that these treatment effects were generally small. We found that most
studies (32 studies) did not report on whether side effects occurred. In the few studies
that did, none of the participants experienced side effects from psychological therapy.
Quality of evidence We rated the quality of the evidence from studies using four levels:
very low, low, moderate, or high. Very low‐quality evidence means that we are very
uncertain about the results. High‐quality evidence means that we are very confident
in the results. There were not enough data to answer some parts of our review questions.
There was sufficient evidence (low to moderate quality) to reach some conclusions
about the effects of psychological therapy for parents of children with cancer and
chronic pain and the effects of CBT and PST.