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      Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects.

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          Abstract

          Suicide is a major public health concern. Although authors of many studies have examined the neurobiological aspects of suicide, the molecular mechanisms associated with suicidal behavior remain unclear. Brain-derived neurotrophic factor (BDNF), one of the most important neurotrophins, after binding with and activating receptor tyrosine kinase B (trk B), is directly involved in many physiological functions in the brain, including cell survival and synaptic plasticity. The present study was performed to examine whether the expression of BDNF and/or trk B isoforms was altered in postmortem brain in subjects who commit suicide (hereafter referred to as suicide subjects) and whether these alterations were associated with specific psychopathologic conditions.

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          Author and article information

          Journal
          Arch Gen Psychiatry
          Archives of general psychiatry
          American Medical Association (AMA)
          0003-990X
          0003-990X
          Aug 2003
          : 60
          : 8
          Affiliations
          [1 ] Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA. ydwivedi@psych.uic.edu
          Article
          60/8/804
          10.1001/archpsyc.60.8.804
          12912764
          ecdb99b8-df67-4329-b201-ca4696ec1b68
          History

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