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      Cytokinesis in animal cells.

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          Abstract

          Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase spindle. Cytokinesis relies on a tight interplay between signaling and cellular mechanics and has attracted the attention of both biologists and physicists for more than a century. In this review, we provide an overview of four topics in animal cell cytokinesis: (a) signaling between the anaphase spindle and cortex, (b) the mechanics of cortical remodeling, (c) abscission, and (d) regulation of cytokinesis by the cell cycle machinery. We report on recent progress in these areas and highlight some of the outstanding questions that these findings bring into focus.

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          Author and article information

          Journal
          Annu Rev Cell Dev Biol
          Annual review of cell and developmental biology
          Annual Reviews
          1530-8995
          1081-0706
          2012
          : 28
          Affiliations
          [1 ] Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA. koegema@ucsd.edu
          Article
          10.1146/annurev-cellbio-101011-155718
          22804577
          ecdbfbe8-f342-491d-ad04-122fe84b5ace
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