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      Obesity and impaired metabolic health in patients with COVID-19

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          Abstract

          Preliminary data suggest that people with obesity are at increased risk of severe COVID-19. However, as data on metabolic parameters (such as BMI and levels of glucose and insulin) in patients with COVID-19 are scarce, increased reporting is needed to improve our understanding of COVID-19 and the care of affected patients.

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          Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

          Zunyou Wu, Jennifer M. McGoogan (2020)
          Article 0 comments Cited 8360 times – based on 0 reviews     Review now
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            Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

            Giacomo Grasselli, Alberto Zangrillo, Alberto Zanella … (2020)
            In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.
            Article 0 comments Cited 2760 times – based on 0 reviews     Review now
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              Covid-19 in Critically Ill Patients in the Seattle Region — Case Series

              Pavan K. Bhatraju, Bijan J Ghassemieh, Michelle Nichols … (2020)
              Abstract Background Community transmission of coronavirus 2019 (Covid-19) was detected in the state of Washington in February 2020. Methods We identified patients from nine Seattle-area hospitals who were admitted to the intensive care unit (ICU) with confirmed infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Clinical data were obtained through review of medical records. The data reported here are those available through March 23, 2020. Each patient had at least 14 days of follow-up. Results We identified 24 patients with confirmed Covid-19. The mean (±SD) age of the patients was 64±18 years, 63% were men, and symptoms began 7±4 days before admission. The most common symptoms were cough and shortness of breath; 50% of patients had fever on admission, and 58% had diabetes mellitus. All the patients were admitted for hypoxemic respiratory failure; 75% (18 patients) needed mechanical ventilation. Most of the patients (17) also had hypotension and needed vasopressors. No patient tested positive for influenza A, influenza B, or other respiratory viruses. Half the patients (12) died between ICU day 1 and day 18, including 4 patients who had a do-not-resuscitate order on admission. Of the 12 surviving patients, 5 were discharged home, 4 were discharged from the ICU but remained in the hospital, and 3 continued to receive mechanical ventilation in the ICU. Conclusions During the first 3 weeks of the Covid-19 outbreak in the Seattle area, the most common reasons for admission to the ICU were hypoxemic respiratory failure leading to mechanical ventilation, hypotension requiring vasopressor treatment, or both. Mortality among these critically ill patients was high. (Funded by the National Institutes of Health.)
              Article 0 comments Cited 1258 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Norbert Stefan: norbert.stefan@med.uni-tuebingen.de
                Journal
                Journal ID (nlm-ta): Nat Rev Endocrinol
                Journal ID (iso-abbrev): Nat Rev Endocrinol
                Title: Nature Reviews. Endocrinology
                Publisher: Nature Publishing Group UK (London )
                ISSN (Print): 1759-5029
                ISSN (Electronic): 1759-5037
                Publication date (Electronic): 23 April 2020
                Pages: 1-2
                Affiliations
                [1 ]Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, Tübingen, Germany
                [2 ]ISNI 0000 0001 0196 8249, GRID grid.411544.1, Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, , University Hospital of Tübingen, ; Tübingen, Germany
                [3 ]GRID grid.452622.5, German Center for Diabetes Research (DZD), ; Neuherberg, Germany
                [4 ]ISNI 000000041936754X, GRID grid.38142.3c, Department of Pediatrics, , Harvard Medical School, ; Boston, MA USA
                [5 ]ISNI 0000 0001 2322 6764, GRID grid.13097.3c, Department of Diabetes, , School of Life Course Science, King’s College London, ; London, UK
                [6 ]ISNI 0000 0004 0390 0098, GRID grid.418213.d, Department of Molecular Epidemiology, , German Institute of Human Nutrition Potsdam-Rehbruecke, ; Nuthetal, Germany
                [7 ]ISNI 000000041936754X, GRID grid.38142.3c, Department of Nutrition, , Harvard T.H. Chan School of Public Health, ; Boston, MA USA
                [8 ]ISNI 0000 0004 0378 8438, GRID grid.2515.3, New Balance Foundation Obesity Prevention Center, , Boston Children’s Hospital, ; Boston, MA USA
                Article
                Publisher ID: 364
                DOI: 10.1038/s41574-020-0364-6
                PMC ID: 7187148
                PubMed ID: 32327737
                SO-VID: ece10314-4d0c-4391-a555-37d9dd289abc
                Copyright © © Springer Nature Limited 2020
                License:

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                Categories
                Subject: Comment

                Keywords: obesity,sars-cov-2
                Data availability:
                Keywords: obesity, sars-cov-2

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