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      Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response.

      1 , 2 , 3

      FEBS letters

      Innate immunity, RLR, Viral sensing

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          Abstract

          Viral triggering of the innate immune response in infected cells aims at delaying viral replication and prevents tissue spreading. Viral replication is delayed by host protein synthesis inhibition and infected cell apoptosis on one hand, while infection spreading is controlled by the synthesis of specific proteins like type-I interferons (IFNs) and pro-inflammatory cytokines on the other hand. How do these two apparent conflicting responses cooperate within the same infected cells to mount effective defenses against pathogens? What are the molecules or the complexes resolving this contradiction over time? Some recent studies reveal unanticipated connections between innate immunity and stress pathways, giving important clues on how the cellular responses are orchestrated to limit infection efficiently.

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          Author and article information

          Journal
          FEBS Lett.
          FEBS letters
          1873-3468
          0014-5793
          Jun 22 2015
          : 589
          : 14
          Affiliations
          [1 ] Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France.
          [2 ] Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France; Institute for Research in Biomedicine - iBiMED and Aveiro Health Sciences Program, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: gatti@ciml.univ-mrs.fr.
          [3 ] Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France; Institute for Research in Biomedicine - iBiMED and Aveiro Health Sciences Program, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: pierre@ciml.univ-mrs.fr.
          Article
          S0014-5793(15)00359-2
          10.1016/j.febslet.2015.05.006
          25979169
          Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

          Viral sensing, Innate immunity, RLR

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