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      Sfrp-1 and sfrp-2 are expressed in overlapping and distinct domains during chick development

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      Mechanisms of Development
      Elsevier BV

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          Abstract

          Secreted frizzled related proteins (Sfrps) are thought to bind and regulate Wnt activity through a cysteine rich domain that is highly similar to that of Frizzled receptors. To investigate possible roles for Sfrps in chick development, we have isolated partial cDNAs encoding Sfrp-1 and Sfrp-2 and have thoroughly characterized the expression patterns of both genes. Both sfrp-1 and sfrp-2 are expressed at all stages of development analyzed, ranging from Hamburger and Hamilton stage 4 through stage 32. Expression of both sfrp-1 and sfrp-2 is observed in mesodermal and ectodermal derivatives, while sfrp-1 is also found in endodermal lineages.

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          Author and article information

          Journal
          Mechanisms of Development
          Mechanisms of Development
          Elsevier BV
          09254773
          October 2000
          October 2000
          : 97
          : 1-2
          : 177-182
          Article
          10.1016/S0925-4773(00)00407-X
          11025221
          ed0da166-198c-4824-9241-d50f1628afda
          © 2000

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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