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Abstract
Secreted frizzled related proteins (Sfrps) are thought to bind and regulate Wnt activity
through a cysteine rich domain that is highly similar to that of Frizzled receptors.
To investigate possible roles for Sfrps in chick development, we have isolated partial
cDNAs encoding Sfrp-1 and Sfrp-2 and have thoroughly characterized the expression
patterns of both genes. Both sfrp-1 and sfrp-2 are expressed at all stages of development
analyzed, ranging from Hamburger and Hamilton stage 4 through stage 32. Expression
of both sfrp-1 and sfrp-2 is observed in mesodermal and ectodermal derivatives, while
sfrp-1 is also found in endodermal lineages.