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      Utility of Cardiac Biomarkers in the Setting of Kidney Disease

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          Cardiovascular disease is prevalent in patients with chronic kidney disease (CKD) and responsible for approximately half of all CKD-related deaths. Unfortunately, the presence of CKD can lead to a challenging interpretation of cardiac biomarkers essential in accurate diagnosis and prompt management of heart failure and acute coronary syndrome. There is growing interest in novel cardiac biomarkers that may improve diagnostic accuracy reflecting myocardial injury, inflammation, and remodeling. Interpretation of these biomarkers in CKD can be complicated, since elevated levels may not reflect myocardial injury or wall tension but rather decreased urinary clearance with retention of solutes and/or overall CKD-associated chronic inflammation. In this review, we discuss the latest data on major and emerging cardiac biomarkers including B-type natriuretic peptide, troponin, suppression of tumorigenicity 2, growth and differentiation factor-15, galectin-3, and matrix gla protein, and their diagnostic and prognostic utility in the CKD population.

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          Author and article information

          S. Karger AG
          April 2019
          06 February 2019
          : 141
          : 4
          : 227-235
          aDepartment of Internal Medicine, Riverside Community Hospital, University of California, Riverside School of Medicine, Riverside, California, USA
          bDivision of Cardiology, University of California, Irvine School of Medicine, Irvine, California, USA
          cNational Research Council (CNR), Institute of Clinical Physiology (IFC), Pisa, Italy
          dDepartment of Medicine, University of Padova, Padova, Italy
          eNephrology and Dialysis Unit, Department of Clinical and Biomedical Sciences “Luigi Sacco”, University of Milan, Milan, Italy
          fDivision of Nephrology, University of California, Irvine School of Medicine, Irvine, California, USA
          Author notes
          *Wei Ling Lau, Division of Nephrology, University of California, 333 City Blvd. West, Suite 400, Irvine, CA 92868 (USA), E-Mail
          495946 Nephron 2019;141:227–235
          © 2019 S. Karger AG, Basel

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          Page count
          Tables: 1, Pages: 9
          Clinical Practice: Review


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