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      Pharmacology of mangostins and their derivatives: A comprehensive review

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          Abstract

          Mangosteen ( Garcinia mangostana Linn.) is a well-known tropical tree indigenous to Southeast Asia. Its fruit’s pericarp abounds with a class of isoprenylated xanthones which are referred as mangostins. Numerous in vitro and in vivo studies have shown that mangostins and their derivatives possess diverse pharmacological activities, such as antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic activities as well as neuroprotective properties in Alzheimer’s disease (AD). This review article provides a comprehensive review of the pharmacological activities of mangostins and their derivatives to reveal their promising utilities in the treatment of certain important diseases, mainly focusing on the discussions of the underlying molecular targets/pathways, modes of action, and relevant structure-activity relationships (SARs). Meanwhile, the pharmacokinetics (PK) profile and recent toxicological studies of mangostins are also described for further druggability exploration in the future.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 February 2017
          : 15
          : 2
          : 81-93
          Affiliations
          1Key Laboratory of Drug Design and Optimization of Jiangsu Province, China Pharmaceutical University, Nanjing 210009, China
          2Higher Vocational and Technical College, China Pharmaceutical University, Nanjing 210009, China
          Author notes
          *Corresponding author: WANG Jin-Xin, Tel: 86-25-83271414, E-mail: jinxinwang@ 123456163.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(17)30024-9
          10.1016/S1875-5364(17)30024-9
          28284429
          Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Leading Entrepreneurship Talents Program of Nanjing, China
          Award ID: 2013B14007
          Funded by: General Program of Social Development in the Plan of Key Research of Jiangsu Province
          Award ID: BE201568
          This work was supported by the Leading Entrepreneurship Talents Program of Nanjing, China (No. 2013B14007) and the General Program of Social Development in the Plan of Key Research of Jiangsu Province (No. BE201568).
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          Review

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