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      HMGB1 as a Key Mediator of Immune Mechanisms in Ischemic Stroke.

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          Abstract

          Stroke is the leading cause of morbidity and mortality worldwide. Inflammatory cascades have a major impact on outcome and regeneration after ischemic stroke. High-mobility group box 1 (HMGB1) has come into the focus of experimental and clinical stroke research because it is released from necrotic brain tissue and its differential redox forms attract and activate immune cells after ischemic brain injury. HMGB1 is a potent inducer of inflammatory cascades, and thereby, secondary deterioration of neurological outcome.

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          Author and article information

          Journal
          Antioxid. Redox Signal.
          Antioxidants & redox signaling
          1557-7716
          1523-0864
          Apr 20 2016
          : 24
          : 12
          Affiliations
          [1 ] 1 Institute for Stroke and Dementia Research , Klinikum der Universität München, Munich, Germany .
          [2 ] 2 Munich Cluster for Systems Neurology (SyNergy) , Munich, Germany .
          [3 ] 3 Division of Brain Sciences, Imperial College London , London, United Kingdom .
          Article
          10.1089/ars.2015.6397
          26493086
          ed54a434-ccb0-45cb-be53-366157a25e87
          History

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