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      • Record: found
      • Abstract: found
      • Article: found

      Retinal Early Receptor Potential in Retinitis pigmentosa: Correlations with Visual Field and Fluoroangiography Estimates

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          Abstract

          The flash induced electroretinogram (ERG) and early receptor potential (ERP) were recorded in a population of patients with definite diagnosis of retinitis pigmentosa in the context of a study protocol including a complete diagnostic screening. ERPs were evoked by full-field 20-joule stimuli (5 stimuli at 10 min of interval in dark adaptation); recording was by skin electrodes positioned at the inferior orbital margin; amplifiers were set at 10–10,000 Hz. The flash ERG was absent or markedly abnormal in all cases, even at an early stage of development of the retinitis, while ERPs (with a normal morphology, latency of the R<sub>1</sub>·component increased and a reduced amplitude compared to normal controls) could be identified unambiguously in all cases. The amplitude reduction was highly correlated with the severity of the disease as determined by kinetic perimetry and fluorangiography.

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          Author and article information

          Journal
          Journal ID (publisher-id): OPH
          Journal ID (nlm-ta): Ophthalmologica
          Journal ID (doi): 10.1159/issn.0030-3755
          Title: Ophthalmologica
          Publisher: S. Karger AG
          ISSN (Print): 0030-3755
          ISSN (Electronic): 1423-0267
          Publication date Subscription-year: 1991
          Publication date (Print): 1991
          Publication date (Electronic): 31 March 2010
          Volume: 203
          Issue: 2
          Pages: 82-88
          Affiliations
          aInstitute of Ophthalmology (Head: Prof. M. Zingirian) and bInstitute of Neurophysiopathology (Head: Prof. G. Rosadini), University of Genoa, Italy
          Article
          Publisher ID: 310231 Other ID: Ophthalmologica 1991;203:82–88
          DOI: 10.1159/000310231
          PubMed ID: 1762724
          SO-VID: ed90a26f-4898-4288-bce1-b4b53016fa77
          Copyright © © 1991 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 01 March 1991
          Date accepted : 22 March 1991
          Page count
          Pages: 7
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Fluoroangiography,Flash electroretinogram,Early receptor potential,Retinitis pigmentosa,Visual field
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Fluoroangiography, Flash electroretinogram, Early receptor potential, Retinitis pigmentosa, Visual field

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