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Left Ventricular Dysfunction Switches Mesenchymal Stromal Cells Toward an Inflammatory Phenotype and Impairs Their Reparative Properties Via Toll-Like Receptor-4Clinical Perspective
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Abstract
Little is known about the potentially unfavorable effects of mesenchymal stromal cell
(MSC) activation on the heart. MSCs can respond to tissue injury by anti- or proinflammatory
activation. We aimed to study the potential negative interaction between left ventricular
dysfunction (LVD) and MSC activation.