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      Spin trapping of nitric oxide produced in vivo in septic-shock mice

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      FEBS Letters

      Elsevier BV

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          Most cited references 18

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          Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

           M Marletta,  D Stuehr (1985)
          Escherichia coli lipopolysaccharide (LPS)-induced nitrate biosynthesis was studied in LPS-sensitive C3H/He and LPS-resistant C3H/HeJ mice. Intraperitoneal injection of 15 micrograms of LPS led to a temporary 5- to 6-fold increase in blood nitrate concentration in the C3H/He strain. Levels of nitrate excreted in the urine were also increased. In contrast, no increase was observed in the C3H/HeJ strain with LPS injections up to 175 micrograms. Furthermore, thioglycolate-elicited peritoneal macrophages from C3H/He, but not from C3H/HeJ mice, produced nitrite (60%) and nitrate (40%) when cultured with LPS (10 micrograms/ml). T-lymphocyte addition/depletion experiments showed the presence of T cells enhanced this response. However, LPS did not cause nitrite or nitrate production in cultures of spleen lymphocytes from either strain. LPS-induced nitrate synthesis was also observed with nude mice and CBA/N mice, indicating that neither functional T lymphocytes nor LPS-responsive B lymphocytes were required for the response in vivo. This was consistent with the in vitro results showing macrophages alone were competent. Mycobacterium bovis infection of C3H/He and C3H/HeJ mice resulted in a large increase in nitrate production over the course of the infection for both strains, suggesting T-lymphocyte-mediated activation of macrophages as a potent stimulus for nitrate biosynthesis. The synthesis of nitrite is significant in that it can directly participate in the endogenous formation of nitrosamines and may also be involved in some aspect of the chemistry of cytotoxicity.
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            Role of endothelium-derived nitric oxide in the regulation of blood pressure.

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              Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite

               Z Vavrin,  R. Taintor,  J Hibbs (1987)
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                Author and article information

                Journal
                FEBS Letters
                Elsevier BV
                00145793
                May 30 1994
                May 30 1994
                : 345
                : 2-3
                : 120-124
                Article
                10.1016/0014-5793(94)00422-6
                eda5a720-4c79-4e2e-9a1a-ffdfaa928caf
                © 1994

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