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      FTICR-MS and LC-UV/MS-SPE-NMR applications for the rapid dereplication of a crude extract from the sponge Ianthella flabelliformis.

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          Abstract

          Dereplication of a methanolic extract of the marine sponge Ianthella flabelliformis using FTICR-MS accurate mass determination and MS(n) techniques enabled rapid and unambiguous detection of a new compound among a plethora of known compounds. Isolation of this compound and the known 19-deoxy analogue using the hyphenated technique LC-UV/MS-SPE-NMR was undertaken, and the structures were confirmed, from a single chromatographic run, as 19-hydroxyaraplysillin-I N(20)-sulfamate (1) and araplysillin-I N(20)-sulfamate (2).

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          Author and article information

          Journal
          J. Nat. Prod.
          Journal of natural products
          American Chemical Society (ACS)
          1520-6025
          0163-3864
          Feb 27 2009
          : 72
          : 2
          Affiliations
          [1 ] Australian Institute of Marine Science, Australia. C.Motti@aims.gov.au
          Article
          10.1021/np800562m
          10.1021/np800562m
          19206511
          eda97291-61ef-48da-9f94-524c6bc8add5
          History

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