This study illustrates the construction and application of comprehensive nursing information service platform based on Internet of Things technology. An Internet-based cardiovascular care management platform, convenient before and after platform application, was constructed; 42 patients with cardiovascular disease were selected as the control group and observation group and 33 nurses participated in the same group, and the intervention lasted for 4 months. The control group received routine admission nursing, and the follow-up nursing nurses received traditional face-to-face teaching, training in the form of assessment. The observation group with the help of the cardiovascular specialist nursing management platform, during the whole process of nursing, nurses also manage patients and receive training through the platform. Experiments show the following: As a result, after the application of the platform, the satisfaction rate of nurses and patients on the platform was high, both reaching more than 92%. After the application of the platform, the scores of various nursing indicators were significantly higher than those before application (all P < 0.01). The construction of a cardiovascular specialist nursing management platform based on IoT technology integrates multiple modules on the medical and patient ends, which not only improves the level of nursing management but also improves the satisfaction of nurses and patients and, at the same time, helps to improve the self-value of nurses.