A neural basis for the spatial suppression of visual motion perception

Abstract

In theory, sensory perception should be more accurate when more neurons contribute to the representation of a stimulus. However, psychophysical experiments that use larger stimuli to activate larger pools of neurons sometimes report impoverished perceptual performance. To determine the neural mechanisms underlying these paradoxical findings, we trained monkeys to discriminate the direction of motion of visual stimuli that varied in size across trials, while simultaneously recording from populations of motion-sensitive neurons in cortical area MT. We used the resulting data to constrain a computational model that explained the behavioral data as an interaction of three main mechanisms: noise correlations, which prevented stimulus information from growing with stimulus size; neural surround suppression, which decreased sensitivity for large stimuli; and a read-out strategy that emphasized neurons with receptive fields near the stimulus center. These results suggest that paradoxical percepts reflect tradeoffs between sensitivity and noise in neuronal populations.

DOI: http://dx.doi.org/10.7554/eLife.16167.001

eLife digest

People usually find it easier to see things when they are big and bright, but there are occasionally exceptions. One example concerns moving objects: when they are small, we can identify their direction of motion easily, but this becomes much more difficult for larger objects. This decreased perceptual sensitivity appears to be linked to other mental processes. For example, studies have suggested that people with high IQs have more difficulty perceiving the motion of large objects, whereas people with various psychiatric disorders, such as schizophrenia, are better able to see such movement. Although several theories have been proposed, there is currently no good explanation for these findings.

Liu et al. set out to determine why the part of the brain that is responsible for vision (the visual cortex) fails to register the direction of large moving objects and how this failure might relate to mental function in general. To do this, Liu et al. trained monkeys to report which direction different sized stimuli were moving on a screen. The electrical activity of nerve cells in the part of the visual cortex that deals with movement was recorded while the monkeys performed this task. The results of the experiments revealed that, on average, these cells responded strongly to large moving stimuli, even though the monkeys had trouble seeing their motion. However, nerve cells are “noisy” – they respond a bit differently every time they are presented with the same stimulus – and this noise was stronger for larger stimuli.

By studying the mathematical relationship between the noise and what the animals perceived, Liu et al. found that the visual cortex attempts to suppress the noise and in the process often shuts off the responses to large stimuli entirely. This suppression is likely to cause the movement of large stimuli to be poorly perceived.

If suppressing this kind of noise is really responsible for failures in perceiving motion, then this mechanism could also explain the connection between motion perception and other mental processes. Liu et al. are currently testing this idea.

DOI: http://dx.doi.org/10.7554/eLife.16167.002