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      The Leu33/Pro polymorphism (PlA1/PlA2) of the glycoprotein IIIa (GPIIIa) receptor is not related to myocardial infarction in the ECTIM Study. Etude Cas-Temoins de l'Infarctus du Myocarde.

      Thrombosis and haemostasis

      Polymorphism, Genetic, Adult, Humans, Leucine, genetics, Male, Middle Aged, Myocardial Infarction, blood, Platelet Aggregation, Platelet Glycoprotein GPIIb-IIIa Complex, Polymerase Chain Reaction

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          Abstract

          The GPIIb/IIIa receptor complex may contribute to acute coronary syndromes by mediating platelet aggregation. The Leu33/Pro polymorphism (PlA1/PlA2) of the GPIIIa has recently been shown to be associated with CHD in a small case-control study. We have investigated this polymorphism in a large multicenter study of patients with myocardial infarction and controls and found no difference in the distribution of allele and genotype frequencies between cases and controls.

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          9241754

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