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      Effects of New Topical β-Mimetic (Isoxuprine and Nylidrine) and β-Lytic (Oxprenolol) Agents on the Ocular Pressure in Glaucomatous Eyes

      Ophthalmic Research

      S. Karger AG

      Glaucoma, Ocular hypotension, β-mimetic and β-lytic drugs, Topical therapy

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          Topical administrations of 1 % solution of both isoxuprine, nylidrin (β-mimetic agents) and of oxprenolol (β-lytic) were found effective in decreasing the intraocular pressure in glaucomatous eyes. No change of the systemic blood pressure occurred. After 8–10 days of treatment with two daily administration, tachyphylaxis begun to be noticed in most cases. Oxprenolol is a nonselective β-receptor-blocking agent, with an intrinsic sympathomimetic activity and a membrane activity. Its administration in 1% solution produced, in glaucomatous eyes, a drop of the ocular pressure with maximum peaks at the 2nd and 3rd hours, and a complete recovery 6–12 h later. A slight myosis was present in 4 of the 6 treated patients. Systemic blood pressure remained unchanged.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 9
          : 4
          : 238-246
          University Eye Clinic of Rome, Rome
          264891 Ophthalmic Res 1977;9:238–246
          © 1977 S. Karger AG, Basel

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          Page count
          Pages: 9


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