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Apoptosis in the failing human heart.
G Olivetti
1 ,
R Abbi ,
F Quaini ,
J Kajstura ,
W Cheng ,
J A Nitahara ,
E Quaini ,
C Di Loreto ,
C A Beltrami ,
S Krajewski ,
J C Reed ,
P Anversa
Apr 17 1997
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Abstract
Loss of myocytes is an important mechanism in the development of cardiac failure of either ischemic or nonischemic origin. However, whether programmed cell death (apoptosis) is implicated in the terminal stages of heart failure is not known. We therefore studied the magnitude of myocyte apoptosis in patients with intractable congestive heart failure.