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      Association of Preoperative Frailty With Intraoperative Hemodynamic Instability and Postoperative Mortality.

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          Abstract

          Frailty, a state of decreased physiological reserve, is strongly associated with perioperative mortality in older adults. However, the mechanism by which frailty is associated with mortality is not yet understood. Autonomic dysfunction in the form of decreased intraoperative hemodynamic variability has been shown to be associated with increased mortality. We aimed to see whether frail patients have less hemodynamic variability under anesthesia and whether variability mediates the relationship between frailty and 30-day mortality.

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          Author and article information

          Journal
          Anesth Analg
          Anesthesia and analgesia
          Ovid Technologies (Wolters Kluwer Health)
          1526-7598
          0003-2999
          June 2019
          : 128
          : 6
          Affiliations
          [1 ] From the Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
          Article
          00000539-201906000-00038
          10.1213/ANE.0000000000004085
          31094800
          edeb613e-5468-4517-a06a-00f5f757eb78
          History

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