Blog
About

18
views
0
recommends
+1 Recommend
0 collections
    1
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Heterogeneity of release probability, facilitation, and depletion at central synapses.

      Neuron

      Animals, Time Factors, physiology, Synaptic Vesicles, Synapses, Receptors, Metabotropic Glutamate, Rats, Patch-Clamp Techniques, Neuronal Plasticity, Neural Inhibition, In Vitro Techniques, Hippocampus, Evoked Potentials, Electric Stimulation, Brain Stem

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Previous studies of short-term plasticity in central nervous systems synapses have largely focused on average synaptic properties. In this study, we use recordings from putative single synaptic release sites in hippocampal slices to show that significant heterogeneity exists in facilitation and depletion among synapses. In particular, the amount of paired-pulse facilitation is inversely related to the initial release probability of the synapse. We also examined depletion at individual synapses using high frequency stimulation, and estimated the size of the readily releasable vesicle pool, which averaged 5.0 +/- 3.0 quanta (n = 13 synapses). In addition, these experiments demonstrate that the release probability at a synapse is directly correlated with the size of its readily releasable vesicle pool.

          Related collections

          Author and article information

          Journal
          9208866

          Comments

          Comment on this article