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      Factors associated with loss to follow up after entry into care of HIV infected children ineligible for antiretroviral therapy: data from an HIV cohort study in India

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      1 , 1 , 1 , 1 ,
      BMC Infectious Diseases
      BioMed Central
      2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014)
      30 January-1 February 2014

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          Abstract

          Background Half of HIV-infected adults who are not eligible for antiretroviral therapy (ART) are lost to follow up (LTFU). However, data about the attrition from enrolment in care to ART eligibility of HIV infected children are scarce. Methods Two hundred and eighty two children ineligible for ART at enrolment in care were followed up until ART eligibility. Multivariable analysis was performed using competing risk regression. The 12-month risk of AIDS was calculated using the age and the absolute CD4 cell count as in the HIV Pediatric Prognostic Markers Collaborative Study. Results The cumulative incidence of attrition (mortality and LTFU) was 15.6% (95% confidence interval [CI], 11.3-20.5) after six years of follow-up, and the attrition rate was higher during the first year after enrolment. Children with a 12-month risk of AIDS < 3% had a higher risk of LTFU (subdistribution hazard ratio [SHR] 10.77, 95% CI 1.93-60.07) than those with a 12-month risk of AIDS >4%. Those children whose father had died had a lower risk of LTFU (SHR 0.26, 95% CI 0.09-0.75) than those whose parents were alive and were living in a rented house. Children aged 10-14 had a lower risk of LTFU (SHR 0.12, 95% CI 0.03-0.55) than those aged 5-9 years. Conclusions A substantial proportion of children ineligible for ART were LTFU before ART eligibility. These findings can be used by HIV programmes to design interventions aimed at reducing the attrition in pre-ART care of HIV infected children in India.

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          Author and article information

          Contributors
          Conference
          BMC Infect Dis
          BMC Infect. Dis
          BMC Infectious Diseases
          BioMed Central
          1471-2334
          2014
          27 May 2014
          : 14
          : Suppl 3
          : O26
          Affiliations
          [1 ]Department of Infectious Diseases, Rural Development Trust Hospital, Bathalapalli, AP, India
          Article
          1471-2334-14-S3-O26
          10.1186/1471-2334-14-S3-O26
          4080347
          edf56ccb-f64b-4821-a052-d77b0398ec47
          Copyright © 2014 Naik et al; licensee BioMed Central Ltd.

          This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

          2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014)
          Chennai, India
          30 January-1 February 2014
          History
          Categories
          Oral Presentation

          Infectious disease & Microbiology
          Infectious disease & Microbiology

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