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      Effect of silicone oil viscosity on emulsification.

      Archives of ophthalmology (Chicago, Ill. : 1960)

      Emulsions, Models, Chemical, Molecular Weight, Silicone Oils, Surface-Active Agents, Viscosity

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          Abstract

          Emulsification of intravitreal silicone oil has been observed as a late complication after its use as a retinal tamponade. We compared the emulsification potential of silicone oil of different viscosities (100 centistokes [cs], 1000 cs, and 12,500 cs) and molecular composition in an in vitro model using a commercial detergent (benzalkonium chloride) and physiologic surface-active agents (human serum and lysed red blood cells). We found that silicone oils that have low-molecular-weight contents emulsify more readily than those that do not. Moreover, the extent and susceptibility to emulsification increases with decreasing viscosity or with an increase in the proportion of low-molecular-weight constituents. Hence, higher-molecular-weight (viscosity) oils or removal of low-molecular-weight components from medical grade fluid may lessen the emulsification observed clinically.

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          Journal
          3566611

          Chemistry

          Emulsions, Models, Chemical, Molecular Weight, Silicone Oils, Surface-Active Agents, Viscosity

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