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      Melanoma biology and new targeted therapy.

      1 , ,
      Nature
      Springer Science and Business Media LLC

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          Abstract

          Melanoma is a cancer that arises from melanocytes, specialized pigmented cells that are found predominantly in the skin. The incidence of melanoma is rising steadily in western populations--the number of cases worldwide has doubled in the past 20 years. In its early stages malignant melanoma can be cured by surgical resection, but once it has progressed to the metastatic stage it is extremely difficult to treat and does not respond to current therapies. Recent discoveries in cell signalling have provided greater understanding of the biology that underlies melanoma, and these advances are being exploited to provide targeted drugs and new therapeutic approaches.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          1476-4687
          0028-0836
          Feb 22 2007
          : 445
          : 7130
          Affiliations
          [1 ] The Institute of Cancer Research, Signal Transduction Team, Cancer Research UK Centre of Cell and Molecular Biology, 237 Fulham Road, London SW3 6JB, UK.
          Article
          nature05661
          10.1038/nature05661
          17314971
          ee003c7c-eca6-40f6-bf51-b8194a306bb1
          History

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