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      Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends

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          Abstract

          Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.

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          Most cited references145

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          Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

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            Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes.

            The metabolism of aerobic organisms continuously produces reactive oxygen species. Although potentially toxic, these compounds also function in signaling. One important feature of signaling compounds is their ability to move between different compartments, e.g. to cross membranes. Here we present evidence that aquaporins can channel hydrogen peroxide (H2O2). Twenty-four aquaporins from plants and mammals were screened in five yeast strains differing in sensitivity toward oxidative stress. Expression of human AQP8 and plant Arabidopsis TIP1;1 and TIP1;2 in yeast decreased growth and survival in the presence of H2O2. Further evidence for aquaporin-mediated H2O2 diffusion was obtained by a fluorescence assay with intact yeast cells using an intracellular reactive oxygen species-sensitive fluorescent dye. Application of silver ions (Ag+), which block aquaporin-mediated water diffusion in a fast kinetics swelling assay, also reversed both the aquaporin-dependent growth repression and the H2O2-induced fluorescence. Our results present the first molecular genetic evidence for the diffusion of H2O2 through specific members of the aquaporin family.
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              Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide.

              Hydrogen peroxide (H2O2) is an important signaling compound that has recently been identified as a new substrate for several members of the aquaporin superfamily in various organisms. Evidence is emerging about the physiological significance of aquaporin-facilitated H2O2 diffusion.
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                Author and article information

                Contributors
                Journal
                Oxid Med Cell Longev
                Oxid Med Cell Longev
                OMCL
                Oxidative Medicine and Cellular Longevity
                Hindawi
                1942-0900
                1942-0994
                2018
                27 March 2018
                : 2018
                : 1501847
                Affiliations
                1Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, Bari, Italy
                2Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
                3Department of Life Sciences, University of Siena, Siena, Italy
                4Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
                5Instituto de Fisiología Experimental, CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina
                Author notes

                Academic Editor: Mark Crabtree

                Author information
                http://orcid.org/0000-0002-8890-0278
                http://orcid.org/0000-0003-0233-0778
                http://orcid.org/0000-0002-6827-7327
                http://orcid.org/0000-0003-4666-9546
                Article
                10.1155/2018/1501847
                5892239
                ee0363b1-074e-41c9-b383-2d37130f79e3
                Copyright © 2018 Grazia Tamma et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 19 October 2017
                : 29 January 2018
                : 20 February 2018
                Funding
                Funded by: Agropolis Foundation
                Award ID: ANR-10-LABX-0001-01
                Funded by: Daniel & Nina Carasso Foundation
                Award ID: 00063479
                Funded by: Fondazione Cariplo
                Award ID: #FC 2015-2440
                Award ID: #1507-200 AF
                Categories
                Review Article

                Molecular medicine
                Molecular medicine

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