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      Clinical Aspects of Uraemic Polyneuropathy

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      Nephron

      S. Karger AG

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          Abstract

          In order to establish the relationship between uraemic polyneuropathy and impairment of renal function, 83 patients with severe renal insufficiency not treated by maintenance dialysis were neurologically examined, most of them repeatedly in the course of their disease. Signs of neuropathy were found only when the creatinine clearance was 5 ml/min or less. The risk of incapacitating neuropathy was present in patients with a creatinine clearance of 3 ml/min or less. Polyneuropathy was found most frequently in patients with the highest blood urea and creatinine levels and the lowest creatinine clearances, but the duration of the period during which renal insufficiency had been severe appeared to be of influence as well. Polyneuropathy could be correlated more closely with the level of breakdown products of protein metabolism in the blood than with the blood creatinine level. The motor conduction velocity of the lateral popliteal nerve was examined in 50 patients. When polyneuropathy progressed, the conduction velocity fell to 50% of the normal value. The protein level of the CSF was raised in most patients with a severe polyneuropathy. Polyneuropathy was assessed in 20 patients treated by maintenance dialysis; it was compared to polyneuropathy in patients without this treatment.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1971
          1971
          26 November 2008
          : 8
          : 5
          : 414-426
          Affiliations
          Renal Department and Neurological Clinic, State University Hospital, Utrecht
          Article
          179946 Nephron 1971;8:414–426
          10.1159/000179946
          4331711
          © 1971 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 13
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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