Saposhnikoviae divaricata : a phytochemical, pharmacological, and pharmacokinetic review

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Saposhnikoviae divaricata (Turcz.) Schischk (SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarins in SD offers an insight to the pharmacological effects of these bioactive constituents as anti-inflammatory, analgesic, immunoregulatory, antioxidative, and anti-proliferative agents. It is highlighted that there is a structural relationship between the constituents and bioactive activities, which in effect provides a valid reasoning and reaffirm the use of SD in the treatment of the pathologies in Chinese medicine.

Most cited references 34

Record: found
Abstract: not found
Article: not found

The pathogenesis of rheumatoid arthritis.

Iain B McInnes, Georg Schett (2012)

0 comments Cited 324 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: outside-in signaling and relationship to tumor progression.

Brigitte Bauvois (2012)

This review focuses on matrix metalloproteinases (MMPs)-2 (gelatinase A) and -9 (gelatinase B), both of which are cancer-associated, secreted, zinc-dependent endopeptidases. Gelatinases cleave many different targets (extracellular matrix, cytokines, growth factors, chemokines and cytokine/growth factor receptors) that in turn regulate key signaling pathways in cell growth, migration, invasion, inflammation and angiogenesis. Interactions with cell surface integral membrane proteins (CD44, αVβ/αβ1/αβ2 integrins and Ku protein) can occur through the gelatinases' active site or hemopexin-like C-terminal domain. This review evaluates the recent literature on the non-enzymatic, signal transduction roles of surface-bound gelatinases and their subsequent effects on cell survival, migration and angiogenesis. Gelatinases have long been drug targets. The current status of gelatinase inhibitors as anticancer agents and their failure in the clinic is discussed in light of these new data on the gelatinases' roles as cell surface transducers - data that may lead to the design and development of novel, gelatinase-targeting inhibitors. Copyright © 2011 Elsevier B.V. All rights reserved.

0 comments Cited 139 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Increases in the activated forms of ERK 1/2, p38 MAPK, and CREB are correlated with the expression of at-level mechanical allodynia following spinal cord injury.

Zaiming Ye, John McAdoo, Eric D. Crown … (2006)

Rats given moderate spinal cord injury (SCI) display increases in the expression of the activated form of the transcription factor cyclic AMP responsive element binding protein (CREB) in spinal segments of dermatomes corresponding to permanent mechanical allodynia, a model of chronic central neuropathic pain (CNP; (Crown, E.D., Ye, Z., Johnson, K.M., Xu, G.Y., McAdoo, D.J., Westlund, K.N., Hulsebosch, C.E., 2005. Upregulation of the phosphorylated form of CREB in spinothalamic tract cells following spinal cord injury: relation to central neuropathic pain. Neurosci. Lett. 384, 139-144)). Given that not all rats that receive moderate SCI develop CNP, the current study was designed to further analyze changes in persistent CREB activation and in the activation state of upstream intracellular signaling cascades (e.g., mitogen-activated protein kinases [MAPKs]) in populations of rats that receive SCI and weeks later develop CNP and rats that receive SCI but do not develop CNP. The results indicate that activated kinases such as pERK 1/2, p-p38 MAPK, but not pJNK, are upregulated in injured rats that develop CNP as compared to injured rats that fail to develop CNP. In addition, the current results replicated our previous finding that activated CREB is upregulated following SCI, however, only in SCI rats that developed CNP. Taken together, these results indicate that activation of intracellular signaling cascades traditionally associated with long-term potentiation and memory is associated with the expression of chronic CNP following SCI.

0 comments Cited 47 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Angela Wei Hong Yang

Journal

Journal ID (nlm-ta): Chin J Nat Med

Journal ID (iso-abbrev): Chin J Nat Med

Title: Chinese Journal of Natural Medicines

Publisher: China Pharmaceutical University. Published by Elsevier B.V.

ISSN (Print): 2095-6975

ISSN (Electronic): 1875-5364

Publication date PMC-release: 18 May 2017

Publication date (Print): April 2017

Publication date (Electronic): 18 May 2017

Volume: 15

Issue: 4

Pages: 255-264

Affiliations

[a ]School of Health and Biomedical Sciences, RMIT University, Victoria 3001, Australia

[b ]School of Science, RMIT University, Victoria 3001, Australia

Author notes

[* ] Corresponding author Tel: 61-3-9925-7175, Fax: 61-3-9925-7178 angela.yang@ 123456rmit.edu.au

Article

Publisher ID: S1875-5364(17)30042-0

DOI: 10.1016/S1875-5364(17)30042-0

PMC ID: 7128302

PubMed ID: 28527510

SO-VID: ee141b28-5131-4e06-bb69-e1b38e1b7aad

License:

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Saposhnikoviae divaricata: a phytochemical, pharmacological, and pharmacokinetic review

Read this article at

Abstract

Most cited references 34

The pathogenesis of rheumatoid arthritis.

New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: outside-in signaling and relationship to tumor progression.

Increases in the activated forms of ERK 1/2, p38 MAPK, and CREB are correlated with the expression of at-level mechanical allodynia following spinal cord injury.

Author and article information

Contributors

Journal

Affiliations

Author notes

Article

History

Categories

Comments

Comment on this article

Similar content 174

Cited by 30

Most referenced authors 410