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      Pregnancy outcome of 149 pregnancies in women with epilepsy: Experience from a tertiary care hospital

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          Abstract

          Introduction

          Epilepsy has a prevalence of 1.65% in adults, and every 1 in 200 pregnancies encounters its complications. We aimed to present the existing condition of and our experience with epileptic pregnant women for whom the prepregnancy counseling is inadequate in Turkey.

          Methods

          We evaluated 149 epileptic pregnant women between March 2009 and January 2015. Demographic features of the patients, along with type and duration of epileptic seizure, time of diagnosis, date of last seizure prior to pregnancy, number and duration of seizures during pregnancy, type of AEDs, result and week of termination of pregnancy, and birth weight were registered, and also, we evaluated perinatal complications and fetal malformations.

          Results

          Mean age of the patients was 27.12 ± 5.4 years, and mean duration from the diagnosis of epilepsy to pregnancy was 9.68 ± 5.91 years. Twenty-seven (18.12%) and 101 (67.78%) patients had polytherapy and monotherapy, respectively. We observed epileptic seizures in 103 (69.12%) patients during pregnancy, and seizures mostly occurred in the first and third trimesters. Forty-one (39.80%) patients had seizures in all three trimesters. Forty-two (28.18%) patients among all patients who had seizures during pregnancy had 5 or more seizures. Major malformations, namely, cleft lip and palate, ventriculoseptal defect, and spina bifida were observed in the patients. Mean birth week was 38.43 ± 1.68 weeks, and mean birth weight was 2965.31 ± 453.94 grams. Twenty-two patients had normal spontaneous vaginal delivery whereas 118 patients had cesarean section.

          Conclusions

          Pregnant women with epilepsy have their own risks. These women should be followed by experienced obstetricians and neurologists during their pregnancies. Appropriate management and follow-up lead to good results almost the same as general population.

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          Author and article information

          Journal
          1646
          Interventional Medicine and Applied Science
          IMAS
          Akadémiai Kiadó
          2061-1617
          September 2015
          : 7
          : 3
          : 108-113
          Affiliations
          Department of Obstetrics and Gynecology, Ankara Numune Education and Research Hospital , Ankara, Turkey
          Author notes
          [*]

          Corresponding author: Ozhan Ozdemir; Department of obstetrics and Gynecology, Ankara Numune Training and Education Hospital, 06010, Ankara, Turkey; Phone: +905052255078; E-mail: seyozi@ 123456hotmail.com

          Article
          10.1556/1646.7.2015.3.4
          4609022
          26527567
          © 2015 Akadémiai Kiadó, Budapest

          This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited.

          Page count
          Pages: 6
          Categories
          Original Paper

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