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      Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo.

      1 ,
      Science (New York, N.Y.)
      American Association for the Advancement of Science (AAAS)

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          Abstract

          A crucial question in the study of immunological reactions in the central nervous system (CNS) concerns the identity of the parenchymal cells that function as the antigen-presenting cells in that organ. Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived. In addition, these perivascular cells are fully competent to present antigen to lymphocytes in an appropriately restricted manner. These findings are important for bone marrow transplantation and for neuroimmunological diseases such as multiple sclerosis.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Jan 15 1988
          : 239
          : 4837
          Affiliations
          [1 ] Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6079.
          Article
          10.1126/science.3276004
          3276004
          ee259a50-dcaa-4585-b7a9-f89cbc45c290
          History

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