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      Macular Lesions in Malignant Arterial Hypertension

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          Abstract

          We produced experimental renovascular malignant arterial hypertension by a modified Goldblatt’s procedure in 60 rhesus monkeys (25 one-kidney model and 35 two-kidney model), and studied various macular lesions by detailed serial ophthalmoscopy, and stereoscopic color fundus photography and fluorescein fundus angiography on a long-term follow-up. The various lesions which developed in the macular region included retinal edema, cystic retinal changes, serous retinal detachment, retinal pigment epithelial changes (initially acute focal and later degenerative lesions), and lipid deposits. In addition to these, the usual retinal lesions associated with hypertensive retinopathy, e.g., focal intraretinal periarteriolar transudates, cotton-wool spots and retinal hemorrhages, were also frequently seen in the macular retina. Findings on the various lesions are described in detail, and the pathogenesis of macular edema in malignant arterial hypertension is discussed.

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          Author and article information

          Journal
          OPH
          Ophthalmologica
          10.1159/issn.0030-3755
          Ophthalmologica
          S. Karger AG
          978-3-8055-4996-7
          978-3-318-05648-8
          0030-3755
          1423-0267
          1989
          1989
          31 March 2010
          : 198
          : 4
          : 230-246
          Affiliations
          Department of Ophthalmology, University of Iowa, Iowa City, Iowa, USA
          Article
          310001 Ophthalmologica 1989;198:230–246
          10.1159/000310001
          2748100
          ee28a635-cefc-4177-b7ab-28aa4e4bef20
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 17
          Categories
          Hypertensive Retinopathy

          Vision sciences,Ophthalmology & Optometry,Pathology
          Cystoid macular edema,Retina,Lipid deposits,Macula,Malignant arterial hypertension,Retinal pigment epithelial,Arterial hypertension,Edema

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