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      Cefsulodin Concentrations in Rabbit Eyes after Intravenous and Subconjunctival Administration

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          Abstract

          Experimental studies on rabbit eyes were performed to examine the penetration capacity of cefsulodin into the anterior chamber and the vitreous body. One group of animals was injected with 50 mg/kg body weight intravenously, the other group received 20 mg subconjunctivally. Samples of the anterior chamber and the vitreous body were taken from the anaesthetized animals after 15, 30, 60 and 120 min (6 eyes at each time). The corresponding serum concentrations were determined as well. Cefsulodin concentrations were measured microbiologically with agar diffusion tests. At each time studied, the antibiotic could be detected in the anterior chamber after intravenous injection. Concentrations ranged from 2 to 5.2 mg/l. Similar results were found after subconjunctival application. In no case the antibiotic was detectable in the vitreous body. The pharmacokinetics of cefsulodin in the rabbit eye seem to be comparable to the behaviour of other β-lactam antibiotics and aminoglycosides. As cefsulodin is able to penetrate into the anterior chamber, it might be a useful antibiotic for therapy of eye infections caused by Pseudomonas aeruginosa

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1982
          1982
          04 December 2009
          : 14
          : 2
          : 129-134
          Affiliations
          Eye Clinic and Institute of Medical Microbiology, University of Bonn, FRG
          Article
          265184 Ophthalmic Res 1982;14:129–134
          10.1159/000265184
          7088497
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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