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Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group.
K K Matthay
1 ,
J G Villablanca ,
R C Seeger ,
D O Stram ,
R E Harris ,
N K Ramsay ,
P Swift ,
H Shimada ,
C T Black ,
G M Brodeur ,
R B Gerbing ,
C P Reynolds
Oct 14 1999
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Abstract
Children with high-risk neuroblastoma have a poor outcome. In this study, we assessed whether myeloablative therapy in conjunction with transplantation of autologous bone marrow improved event-free survival as compared with chemotherapy alone, and whether subsequent treatment with 13-cis-retinoic acid (isotretinoin) further improves event-free survival.