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      Comparación de actividad in vitro anti-Staphylococcus aureus de ocho antibióticos y cuatro diluciones de propóleos Translated title: Comparison of in vitro anti-Staphylococcus aureus activity of eight antibiotics and four dilutions of propolis


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          Resumen El objetivo de esta investigación se basó en la comparación de halos de inhibición de una muestra de Staphylococcus aureus, enfrentada in vitro a ocho antibióticos de uso en medicina, así como, al enfrentamiento a cuatro concentraciones alcohólicas de propóleos. Los resultados señalan que la acción antimicrobiana de propóleos, depende de los compuestos bioactivos como: flavonoides, polifenoles, ácidos aromáticos, etc., contenidos en este producto. La actividad antibacteriana de las cuatro diluciones de propóleos, produjeron halos de inhibición entre 10 y 20 mm. De los ocho antibióticos con los que se realizó la comparación, solo la eritromicina resultó ser resistente a S. aureus. La penicilina produjo los halos con menores dimensiones. Aunque los halos derivados por el resto de los antimicrobianos fueron mayores a los del propóleos, muchos de ellos se encontraron dentro del rango originado por dicho producto de la colmena, no se ha demostrado resistencia antibacteriana comparada, con la que a lo largo de los años los antibióticos presentan, al ser usados indiscriminadamente para eliminar o controlar agentes antimicrobianos.

          Translated abstract

          Abstract The objective of this research was based on the comparison of inhibition halos of a sample of Staphylococcus aureus, faced in vitro with eight antibiotics used in medicine, as well as four alcoholic concentrations of propolis. The results indicate that the antimicrobial action of propolis, depending on the bioactive compounds such as: flavonoids, polyphenols, aromatic acids, etc., contained in this product. The antibacterial activity of the four propolis dilutions produced inhibition halos between 10 and 20 mm. Of the eight antibiotics with which the comparison was made, only erythromycin was found to be resistant to S. aureus. Penicillin produced halos with smaller dimensions. Although the halos derived from the rest of the antimicrobials were greater than those from propolis, many of them were found within the range originated by said product from the hive. Compared antibacterial resistance has not been demonstrated, with which over the year’s antibiotics present, when used indiscriminately to eliminate or control antimicrobial agents

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          Flavonoids: an overview

          Flavonoids, a group of natural substances with variable phenolic structures, are found in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine. These natural products are well known for their beneficial effects on health and efforts are being made to isolate the ingredients so called flavonoids. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Research on flavonoids received an added impulse with the discovery of the low cardiovascular mortality rate and also prevention of CHD. Information on the working mechanisms of flavonoids is still not understood properly. However, it has widely been known for centuries that derivatives of plant origin possess a broad spectrum of biological activity. Current trends of research and development activities on flavonoids relate to isolation, identification, characterisation and functions of flavonoids and finally their applications on health benefits. Molecular docking and knowledge of bioinformatics are also being used to predict potential applications and manufacturing by industry. In the present review, attempts have been made to discuss the current trends of research and development on flavonoids, working mechanisms of flavonoids, flavonoid functions and applications, prediction of flavonoids as potential drugs in preventing chronic diseases and future research directions.
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            Antibacterial, antifungal and antiviral activity of propolis of different geographic origin.

            Propolis samples from different geographic origins were investigated for their antibacterial (against Staphylococcus aureus and Escherichia coli), antifungal (against Candida albicans) and antiviral (against Avian influenza virus) activities. All samples were active against the fungal and Gram-positive bacterial test strains, and most showed antiviral activity. The activities of all samples were similar in spite of the differences in their chemical composition. In samples from the temperate zone, flavonoids and esters of phenolic acids are known to be responsible for the above mentioned activities of bee glue; tropical samples did not contain such substances but showed similar activities. Obviously, in different samples, different substance combinations are essential for the biological activity of the bee glue. It seems that propolis has general pharmacological value as a natural mixture and not as a source of new powerful antimicrobial, antifungal and antiviral compounds.
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              Propolis: is there a potential for the development of new drugs?

              Propolis has plenty of biological and pharmacological properties and its mechanisms of action have been widely investigated in the last years, using different experimental models in vitro and in vivo. Researchers have been interested in the investigation of isolated compounds responsible for propolis action; however, there is lack of clinical research on the effects of propolis. Since propolis-containing products have been marketed and humans have used propolis for different purposes, the goal of this review is to discuss the potential of propolis for the development of new drugs, by comparing data from the literature that suggest candidate areas for the establishment of drugs against tumors, infections, allergy, diabetes, ulcers and with immunomodulatory action. The efficacy of propolis in different protocols in vitro and in vivo suggests its therapeutic properties, but before establishing a strategy using this bee product, it is necessary to study: (a) the chemical nature of the propolis sample. (b) Propolis efficacy should be compared to well-established parameters, e.g. positive or negative controls in the experiments. Moreover, possible interactions between propolis and other medicines should be investigated in humans as well. (c) Clinical investigation is needed to evaluate propolis potential in patients or healthy individuals, to understand under which conditions propolis may promote health. Data point out the importance of this research field not only for the readers and researchers in the scientific community waiting for further clarification on the potential of propolis but also for the pharmaceutical industry that looks for new drugs. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

                Author and article information

                Journal of the Selva Andina Research Society
                J. Selva Andina Res. Soc.
                Órgano oficial de la:; SELVA ANDINA RESEARCH SOCIETY (La Paz, , Bolivia )
                : 13
                : 1
                : 35-48
                [1] Sancti Spírítus orgnameDesarrollo del Ministerio de la Agricultura de Cuba orgdiv1Laboratorio de Referencia para Investigación y Salud Apícola (LARISA) Cuba desarrollo@ 123456larisaulcsa.minag.gob.cu
                [2] La Havana La Habana orgnameCentro de Inmunología Molecular Cuba
                [3] La Havana orgnameHospital Ortopédico Docente Fructuoso Rodríguez Cuba alduque@ 123456infomed.sld.cu
                [4] Sancti Spíritus orgnameCentro Universitario de Sancti Spíritus orgdiv1Facultad de Ciencias Agropecuarias Cuba juanemilio@ 123456uniss.edu.cu
                S2072-92942022000100035 S2072-9294(22)01300100035

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                : 01 April 2021
                : 01 December 2021
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 44, Pages: 14

                SciELO Bolivia


                inhibición,Propóleos,extracto etanólico,antimicrobiano,halos,Propolis,ethanolic extract,antimicrobial,inhibition


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