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      Effects of Ascorbic Acid and its 2-Sulfate on Rabbit Aortic Intimal Thickening

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          Abstract

          Effects of intravenously injected L-ascorbic acid or L-ascorbic acid 2-sulfate on aortic intimal thickening were examined histologically, qualitatively, and quantitatively in the upper, middle and lower thoracic aortic positions of cholesterol-induced atherosclerotic rabbits. A means of evaluating the degree of pathology of the aortic positions was developed employing five descriptive statistics of intimal thickening. Both L-ascorbic acid and L-ascorbic acid 2-sulfate inhibited intimal thickening. The most significant reductions were observed in the upper thoracic aorta.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1977
          1977
          18 September 2008
          : 14
          : 3
          : 157-174
          Affiliations
          Departments of Biochemistry, Biology and Entomology, Pesticide Research Laboratory, Pennsylvania State University, University Park, Pa.
          Article
          158123 Blood Vessels 1977;14:157–174
          10.1159/000158123
          ee521e04-ac31-4e70-bfa1-1de22f60a375
          © 1977 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 19 July 1976
          : 01 November 1976
          Page count
          Pages: 18
          Categories
          Paper

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Atherosclerosis,L-Ascorbic acid,L-Ascorbic acid 2-sulfate,Reduced intimal thickening,Cholesterol-induced atherosclerosis,Quantification of intimal thickening

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