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      Mechanisms by Which Smooth Muscle Sensitivity May Be Altered by Calcium

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          Abstract

          6-Hydroxydopamine (6-OHDA) increased the sensitivity of rat, rabbit and guinea pig portal veins to norepinephrine (NE), methoxamine (ME), barium (Ba<sup>++</sup>) and calcium (Ca<sup>++</sup>) but not to potassium (K<sup>+</sup>). Reserpine potentiated the responses of NE, ME and Ca<sup>++</sup> but not Ba<sup>++</sup> or K<sup>+</sup> in rabbit and guinea pig veins and did not alter the sensitivity of rat veins to all agonists tested. Cocaine only potentiated the NE responses of the veins and decreased the sensitivity of rabbit and guinea pig veins to K<sup>+</sup>. 6-OHDA increased <sup>45</sup>Ca-influx in all veins whereas reserpine increased <sup>45</sup>Ca -influx only in rabbit and guinea pig veins. Cocaine failed to increase <sup>45</sup>Ca-influx in all veins tested. NE, ME and K<sup>+</sup> increased <sup>45</sup>Ca-influx in the veins from the different animals. The agonist-induced <sup>45</sup>Ca-influx was greater in most of the supersensitive veins than in the control veins. In veins that failed to develop supersensitivity, agonist-induced <sup>45</sup>Ca-influx did not differ from that of the control veins. It is concluded that the development of super- and subsensitivity exhibits species variation and that the alteration in Ca<sup>++</sup> influx would be consistent with the changes in sensitivity of the venous smooth muscle.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          978-3-8055-2857-3
          978-3-318-02028-1
          1018-1172
          1423-0135
          1978
          1978
          18 September 2008
          : 15
          : 1-3
          : 93-109
          Affiliations
          University of Hawaii, Department of Pharmacology, School of Medicine, Biomedical Sciences Bldg., Honolulu, Hawaii
          Article
          158156 Blood Vessels 1978;15:93–109
          10.1159/000158156
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 17
          Categories
          Molecular and Cellular Aspects of Vascular Smooth Muscle in Health and Disease

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