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      Xanthine oxidoreductase and neurological sequelae of carbon monoxide poisoning.

      1 , ,

      Toxicology letters

      Elsevier BV

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          Abstract

          Neurological sequelae (NS) is a common complication of carbon monoxide (CO) poisoning and structural alterations of myelin basic protein have been proven to initiate immunological reactions leading to NS. To determine whether xanthine oxidoreductase (XOR) participates in the pathophysiology of CO-mediated NS, we examined myelin basic protein in CO poisoned XOR-depleted rats and performed radial maze studies to evaluate the alteration of cognitive function. Carbon monoxide poisoned XOR-depleted rats did not exhibit myelin basic protein alterations or impaired cognitive function, both found in CO poisoned control rats. These results indicate that XOR is essential to the pathological cascade of CO-mediated NS.

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          Author and article information

          Journal
          Toxicol. Lett.
          Toxicology letters
          Elsevier BV
          0378-4274
          0378-4274
          Apr 25 2007
          : 170
          : 2
          Affiliations
          [1 ] Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA. adrianhst@gmail.com <adrianhst@gmail.com>
          Article
          S0378-4274(07)00074-4 NIHMS23782
          10.1016/j.toxlet.2007.02.006
          2723845
          17433579

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