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      Minireview: the role of oxidative stress in relation to caloric restriction and longevity.

      1 ,
      Endocrinology
      The Endocrine Society

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          Abstract

          Reduction of caloric intake without malnutrition is one of the most consistent experimental interventions that increases mean and maximum life spans in different species. For over 70 yr, caloric restriction has been studied, and during the last years the number of investigations on such nutritional intervention and aging has dramatically increased. Because caloric restriction decreases the aging rate, it constitutes an excellent approach to better understand the mechanisms underlying the aging process. Various investigations have reported reductions in steady-state oxidative damage to proteins, lipids, and DNA in animals subjected to restricted caloric intake. Most interestingly, several investigations have reported that these decreases in oxidative damage are related to a lowering of mitochondrial free radical generation rate in various tissues of the restricted animals. Thus, similar to what has been described for long-lived animals in comparative studies, a decrease in mitochondrial free radical generation has been suggested to be one of the main determinants of the extended life span observed in restricted animals. In this study we review recent reports of caloric restriction and longevity, focusing on mitochondrial oxidative stress and the proposed mechanisms leading to an extended longevity in calorie-restricted animals.

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          Author and article information

          Journal
          Endocrinology
          Endocrinology
          The Endocrine Society
          0013-7227
          0013-7227
          Sep 2005
          : 146
          : 9
          Affiliations
          [1 ] Department of Animal Physiology-II, Faculty of Biology, Complutense University, Madrid, Spain.
          Article
          en.2005-0378
          10.1210/en.2005-0378
          15919745
          ee804b10-02b7-471b-87fd-535f66802965
          History

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