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Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury.
T Yoshida
1 ,
N Maulik ,
R M Engelman ,
Y S Ho ,
J L Magnenat ,
J A Rousou ,
J E Flack ,
D Deaton ,
D K Das
Nov 04 1997
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Abstract
To test our hypothesis that intracellular antioxidant enzymes constitute a cellular defense against acute stress, we studied myocardial ischemia reperfusion injury in the setting of reduced level of glutathione peroxidase using GSHPx-1 gene knockout mice.