A strong and rapid immunosuppression by extracellular ROS- cleaving enzymes (GSH-peroxidase, catalase, MnSOD, CuZnSOD) gives evidence for a permanent, O2illegible??? and O22− maintained intercellular cross talk, even in the resting state ROS- cleaving enzymes as novel immunosuppressants and HO2 and H2O2 as well as NH3 and polyamines as novel “second messengers”
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