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      FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research

      1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 2 , 10 , 1 , 7 , 11 , 7 , 12 , 4 , 13 , 14 , 15 , 16 , 17 , 7 , 18 , 5 , 19 , 20 , 17 , 17 , 4 , 2 , 21 , 17 , 7 , 22 , 23 , 24 , 2 , 4 , 15 , 17 , 1 , 1
      Development
      The Company of Biologists

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          ABSTRACT

          The FaceBase Consortium was established by the National Institute of Dental and Craniofacial Research in 2009 as a ‘big data’ resource for the craniofacial research community. Over the past decade, researchers have deposited hundreds of annotated and curated datasets on both normal and disordered craniofacial development in FaceBase, all freely available to the research community on the FaceBase Hub website. The Hub has developed numerous visualization and analysis tools designed to promote integration of multidisciplinary data while remaining dedicated to the FAIR principles of data management (findability, accessibility, interoperability and reusability) and providing a faceted search infrastructure for locating desired data efficiently. Summaries of the datasets generated by the FaceBase projects from 2014 to 2019 are provided here. FaceBase 3 now welcomes contributions of data on craniofacial and dental development in humans, model organisms and cell lines. Collectively, the FaceBase Consortium, along with other NIH-supported data resources, provide a continuously growing, dynamic and current resource for the scientific community while improving data reproducibility and fulfilling data sharing requirements.

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          Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.

          Neural crest cells are multipotential stem cells that contribute extensively to vertebrate development and give rise to various cell and tissue types. Determination of the fate of mammalian neural crest has been inhibited by the lack of appropriate markers. Here, we make use of a two-component genetic system for indelibly marking the progeny of the cranial neural crest during tooth and mandible development. In the first mouse line, Cre recombinase is expressed under the control of the Wnt1 promoter as a transgene. Significantly, Wnt1 transgene expression is limited to the migrating neural crest cells that are derived from the dorsal CNS. The second mouse line, the ROSA26 conditional reporter (R26R), serves as a substrate for the Cre-mediated recombination. Using this two-component genetic system, we have systematically followed the migration and differentiation of the cranial neural crest (CNC) cells from E9.5 to 6 weeks after birth. Our results demonstrate, for the first time, that CNC cells contribute to the formation of condensed dental mesenchyme, dental papilla, odontoblasts, dentine matrix, pulp, cementum, periodontal ligaments, chondrocytes in Meckel's cartilage, mandible, the articulating disc of temporomandibular joint and branchial arch nerve ganglia. More importantly, there is a dynamic distribution of CNC- and non-CNC-derived cells during tooth and mandibular morphogenesis. These results are a first step towards a comprehensive understanding of neural crest cell migration and differentiation during mammalian craniofacial development. Furthermore, this transgenic model also provides a new tool for cell lineage analysis and genetic manipulation of neural-crest-derived components in normal and abnormal embryogenesis.
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            Registration and landmarking of polygonal mesh facial scans using a point feature based iterative point correspondence algorithm

            Bannister (2017)
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              Author and article information

              Contributors
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              Journal
              Development
              Development
              The Company of Biologists
              0950-1991
              1477-9129
              September 21 2020
              September 15 2020
              September 21 2020
              September 15 2020
              : 147
              : 18
              : dev191213
              Affiliations
              [1 ]Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
              [2 ]Program in Craniofacial Biology, Departments of Orofacial Sciences and of Anatomy, Institute of Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA
              [3 ]Structural Informatics Group, Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
              [4 ]Information Sciences Institute, Viterbi School of Engineering, University of Southern California, Marina del Rey, CA 90292, USA
              [5 ]Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
              [6 ]Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA
              [7 ]Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
              [8 ]Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
              [9 ]Department of Cell Biology and Anatomy, Alberta Children's Hospital Research Institute, and McCaig Bone and Joint Institute, University of Calgary, Alberta, Canada
              [10 ]Department of Orthopedic Research, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
              [11 ]Department of Cell and Developmental Biology, School of Medicine, University of Colorado, Aurora, CO 80045, USA
              [12 ]Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado, Aurora, CO 80045, USA
              [13 ]Program in Craniofacial Biology, Departments of Orofacial Sciences and Pediatrics, Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA
              [14 ]Department of Human Genetics, Emory University, Atlanta, GA 30322, USA
              [15 ]Department of Craniofacial Biology, School of Dental Medicine, University of Colorado, Aurora, CO 80045, USA
              [16 ]Massachusetts General Hospital, Plastic and Reconstructive Surgery, Boston, MA 02114, USA
              [17 ]Departments of Chemical and Systems Biology and of Developmental Biology, Howard Hughes Medical Institute, School of Medicine, Stanford University, Stanford, CA 94305, USA
              [18 ]Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
              [19 ]Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
              [20 ]Clinical and Translational Science, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
              [21 ]Human Medical Genetics and Genomics Program, School of Medicine, University of Colorado, Aurora, CO 80045, USA
              [22 ]Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
              [23 ]U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
              [24 ]School of Natural Sciences, University of California Merced, Merced, CA 95343, USA
              Article
              10.1242/dev.191213
              32958507
              eea1d4d0-9861-4c3f-85b9-a5546e59337b
              © 2020

              http://www.biologists.com/user-licence-1-1/

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