Objective This study explored the interaction between HIV and HCV in vivo and the changes of cellular immune function in the early stage of co-infection, and provide important information for clinical diagnosis and treatment.
Methods Patients with HIV and HCV co-infection admitted to the Eighth People’s Hospital of Guangzhou from January 2017 to December 2019 were selected as the study subjects. Patients with HIV mono-infection or HCV mono-infection were selected as the control group. We retrospectively analyzed and compared the cellular immune function and viral load in each group, and discussed the correlation of HIV and HCV viral load, and the correlation of viral load with CD4 +T lymphocytes.
Results CD45 + lymphocyte count was 702.50 (443.25, 1 788.50) cells/μL, CD3 + lymphocyte count was 564.00 (356.00, 1 337.75) cells/μL, CD4 + lymphocyte count was 75.50 (25.50, 179.00) cells/μL, CD8 + lymphocyte count was 506.50 (315.50, 1 030.50) cells/μL, CD4 +/CD8 + ratio was 0.13 (0.06, 0.23) in the HIV/HCV group, and there were not significantly different from those in HIV group ( P>0.05). CD45 +, CD4 + lymphocyte count and CD4 +/CD8 + ratio in HIV/HCV group were significantly lower than those in HCV group, with statistically significant differences ( P<0.05). The HIV viral load was 4.82 (3.81, 5.54) log 10 copy/mL in HIV/HCV group and 5.24 (4.23, 6.00) log 10 copy/mL in HIV group, with no statistically significant difference between two groups ( P>0.05). HCV viral load was 6.75 (4.77, 7.47) log 10 copy/mL in HIV/HCV group and 6.47 (5.91, 7.04) log 10 copy/mL in HCV group, with no statistically significant difference between two groups ( P>0.05). There was obvious negative correlation between HIV viral load and CD4 +T lymphocytes ( r=-0.525, P=0.017), and no significant correlation between HCV viral load and CD4 +T lymphocytes ( P>0.05), and no significant correlation between HIV and HCV viral load in HIV/HCV group ( r=-0.040, P=0.842).
Conclusion No interaction between HIV and HCV in the early stage of the HIV and HCV coinfection has been found.
摘要:目的 探讨HIV与HCV合并感染早期患者细胞免疫功能和病毒载量的变化,为临床诊疗提供基础数据依 据。 方法 以广州市第八人民医院2017年1月一2019年12月收治HIV与HCV合并感染的首诊患者为研究对象,同时 另选取HIV单独感染患者和HCV单独感染患者作为对照组。回顾性分析各组患者细胞免疫功能及病毒载量,并进行 HIV与HCV病毒载量、病毒载量与CD4 +T淋巴细胞的相关性分析。 结果 HIV/HCV组CD45 +、CD3 +、CD4 +和CD8 +淋巴 细胞计数中位数分别为 702.50(443.25,1 788.50) cells/μL,564.00(356.00,1 337.75) cells/μL,75.50(25.50,179.00) cells/μL和 506.50(315.50,1 030.50) cells/μL,CD4 +/CD8 +比值中位数为 0.13(0.06,0.23),与 HIV组比较,差异均无统计学意义 ( P>0.05)。HIV/HCV组CD45 +、CD4 +淋巴细胞计数、CD4 +/CD8 +比值显著低于HCV组,差异有统计学意义( P<0.05)。 HIV/HCV 组 HIV 病毒载量为 4.82(3.81,5.54)log 10。copy/mL,HIV组为 5.24(4.23,6.00)log 10, copy/mL,差异无统计学意义 ( P>0.05)。HIV/HCV 组 HCV病毒载量为 6.75(4.77,7.47) log 10。copy/mL’HCV组为 6.47(5.91,7.04) log 10。copy/mL,差异无 统计学意义( P>0.05)。HIV/HCV组HIV病毒载量与CD4 +T淋巴细胞存在明显的负相关性( r=-0.525, P=0.017),HCV病 毒载量与CD4 +T淋巴细胞无显著相关性( P>0.05)。HIV/HCV组HIV、HCV病毒载量无显著相关性( r=-0.040, P=0.842)。 结论 暂未发现HIV与HCV合并感染后在疾病的早期两种病毒出现相互影响。