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      Fatty Acids in Nephrotic Syndrome and Chronic Kidney Disease.

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          Abstract

          The role of fatty acids (FAs) in inflammation and in the related chronic diseases has been demonstrated. However, there is a lack of consistent and agreed knowledge about the role of FA profile and renal physiology and pathology, most articles focusing on the effect of polyunsaturated FAs supplementation, without considering the impact of basal FA metabolism on the efficacy of the supplementation. Here, we have summarized the specific literature concerning the assessment of circulating FA in 2 renal diseases, namely nephrotic syndrome and chronic kidney disease, also under hemodialytic treatment, and have received the most significant contributions in the last years. The effects of changes of FA profile and metabolism and the possible involvement of polyunsaturated FA metabolites in raising and modulating inflammation are discussed.

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          Author and article information

          Journal
          J Ren Nutr
          Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
          Elsevier BV
          1532-8503
          1051-2276
          May 2018
          : 28
          : 3
          Affiliations
          [1 ] Pediatric Department of Nephrology Dialysis and Transplantation, IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: stefano.turolo@gmail.com.
          [2 ] Pediatric Department of Nephrology Dialysis and Transplantation, IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
          [3 ] Pediatric Clinic IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
          [4 ] Nutrition Foundation of Italy, Milan, Italy.
          [5 ] Pediatric Department of Nephrology Dialysis and Transplantation, IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy; Pediatric Clinic IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
          Article
          S1051-2276(17)30193-0
          10.1053/j.jrn.2017.08.005
          29153556

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