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      De novo AL Amyloid in a Renal Allograft

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          A 65-year-old woman developed nephrotic syndrome 7 years after receiving a cadaveric renal allograft. Renal biopsy and clinical laboratory evaluation revealed the underlying disease process to be AL amyloidosis. To our knowledge, this is the first reported case of de novo AL amyloid occurring in a renal allograft.

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          Effect of long-term azathioprine administration in adults with minimal-change glomerulonephritis and nephrotic syndrome resistant to corticosteroids.

           R Cade,  D. Mars,  M. Privette (1986)
          Thirteen adult patients with nephrotic syndrome resistant to corticosteroid administration were treated with azathioprine daily for four years. Progressive improvement occurred in all 13 patients so that they were in complete remission after one to three years. The onset of apparent improvement was earlier and the rate of progressive improvement more rapid in patients who had selective proteinuria before therapy than in those whose proteinuria was nonselective. One patient who stopped therapy after 20 months suffered relapse but again responded when azathioprine treatment was restarted. Observation after the four-year therapeutic period ranges from three to 15 years; there have been no relapses during this time.

            Author and article information

            Am J Nephrol
            American Journal of Nephrology
            S. Karger AG
            February 1998
            16 January 1998
            : 18
            : 1
            : 67-70
            a Department of Pathology, University of Washington School of Medicine, Seattle, Wash., and b Providence Alaska Medical Center, Anchorage, Alaska, USA
            13308 Am J Nephrol 1998;18:67–70
            © 1998 S. Karger AG, Basel

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            Figures: 4, References: 7, Pages: 4
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