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Placental site trophoblastic tumor (PSTT) in mother and child: first report of PSTT in infancy.

Medical and pediatric oncology

surgery, Adult, Fatal Outcome, Female, Humans, Hysterectomy, Infant, Liver Neoplasms, pathology, Lung Neoplasms, secondary, Male, Pregnancy, Trophoblastic Tumor, Placental Site, Uterine Neoplasms

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      To the authors' knowledge, placental site trophoblastic tumors occurring simultaneously in mother and infant have not previously been reported. The clinicopathologic features of metastatic placental site trophoblastic tumor in a mother and her 4-month-old son are described. The disease in the infant was aggressive, and he died in multiorgan failure within 5 weeks of hospital admission. Autopsy showed widespread metastases to liver, lungs, pleura, kidney, mesentery and lymph nodes. The mother, who had a uterine tumor and lung metastases, was treated with chemotherapy and hysterectomy and has no evidence of disease 26 months post-treatment. This report shows that placental site trophoblastic tumors can metastasize in both mother and child. Copyright 2002 Wiley-Liss, Inc.

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