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      Crema epitelizante de clorofila, carotenos y vitaminas aplicada en heridas abiertas experimentales

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          Abstract

          La crema con 5 % de un concentrado de clorofila, carotenos y vitaminas, extraído de Pinus caribaea Morelet, fue aplicada diariamente sobre heridas abiertas en ratones Balb/c durante todo el período de regeneración hística. El examen de las biopsias tomadas a los 21 días de realizadas las heridas dio como resultado una epitelización altamente significativa al compararlas con las del grupo control.

          Translated abstract

          The cream with chlorophyll concentrate 5 %, carotenes and vitamins extracted from Pinus caribaea Morelet was daily applied on open wounds in inbred Balb/c mice during the whole period of histic regeneration. The examination of the biopsies taken 21 days later showed a highly significant epithelization on comparing them with those of the control group.

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          Most cited references 26

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          Tratado de Fisiología Médica

           CG Guyton,  JE HALL,  A Guyton (2006)
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            Patients with chronic leg ulcers show diminished levels of vitamins A and E, carotenes, and zinc.

            Nutrition plays an important role in the wound healing process, particularly in the elderly. Comparison of nutritional serum indices between patients with chronic leg ulcers and an age-matched control population. Seventeen patients with chronic leg ulcers (age range 47-90) were studied. A panel of vitamins (A, B1, B2, B6, B12, E), trace elements (zinc, copper, iron), folate, and carotene levels were screened on fasting blood samples. Study data were compared with data obtained from the nutritional status survey (NSS) in the greater Boston area. Significantly lower levels of vitamin A (P < 0.0001), zinc (P < 0. 0001 men, P = 0.027 women) and carotenes (P = 0.0023 men, P = 0.0067 women) were found in chronic ulcer patients. Significantly lower levels of vitamin E (P < 0.009) were observed in the men with a tendency to lower levels in women. Elderly Bostonian patients with chronic leg ulcers have low levels of vitamins A and E, carotenes, and zinc. Nutritional deficiency or increased consumption of nutritional elements in these patients may influence wound healing rates.
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              Inhibitory effect of pheophorbide a, a chlorophyll-related compound, on skin tumor promotion in ICR mouse.

              Anti-tumor-promoting activity of pheophorbide a (PPBa) a chlorophyll-related compound, was examined in a two-stage carcinogenesis experiment in ICR mouse skin by 7,12-dimethylbenz[a] anthracene (DMBA, 0.19 mumol) and 12-O-tetradecanoylphorbol-13-acetate (TPA, 1.6 nmol). Topical application of PPBa (160 nmol) markedly reduced the average number of tumors per mouse and the ratio of tumor-bearing mice (inhibitory ratio: IR = 56%, P < 0.01 and 31%, P < 0.005, respectively). PPBa exhibited potent anti-inflammatory activity in ICR mouse ears and moderate inhibitory activity toward TPA-induced superoxide (O2-) generation in differentiated HL-60 cells. While CuPPBa, a synthetic copper complex of PPBa, exhibited higher anti-inflammatory activity than that of indomethacin, it showed little antioxidative effect against formation of lipid hydroperoxides (LOOHs) and malondialdehyde (MDA), suggesting that the antioxidative effect of PPBa might not be important for anti-inflammatory activity. These results imply that the active mechanism of PPBa for anti-tumor promotion might be partly involved in inhibition of TPA-induced inflammatory responses by suppressing leukocyte activation.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                mil
                Revista Cubana de Medicina Militar
                Rev Cub Med Mil
                ECIMED (Ciudad de la Habana )
                1561-3046
                November 2001
                : 30
                : 4
                : 236-240
                Affiliations
                [1 ] Laboratorio de Medicina Herbaria Cuba
                Article
                S0138-65572001000400004
                Product
                Product Information: website
                Categories
                MEDICINE, LEGAL
                MEDICINE, RESEARCH & EXPERIMENTAL

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